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Easy Creamy Chicken Spinach Alfredo Penne – High-Protein Family Favorite Pasta

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This Creamy Chicken Spinach Alfredo Penne is a rich, high-protein comfort food dinner loaded with tender seasoned chicken, fresh spinach, and penne pasta coated in a silky homemade garlic Parmesan Alfredo sauce. Perfect for family meals, meal prep, or satisfying weeknight dinners.

  • Total Time: 1 hour 50 minutes
  • Yield: 6 servings 1x

Ingredients

Scale
  • 16 oz penne pasta
  • 2 large chicken breasts, diced
  • 2 cups fresh spinach
  • 1 tsp salt
  • 1 tsp black pepper
  • 1 tsp garlic powder
  • 1 tsp Italian seasoning
  • 2 tbsp olive oil
  • 3 tbsp butter
  • 5 cloves garlic, minced
  • 1 1/2 cups heavy cream
  • 1 cup whole milk
  • 1 1/4 cups grated parmesan cheese
  • 2 tbsp chopped parsley (optional)
  • 1/2 tsp crushed red pepper flakes (optional)

Instructions

  1. Season chicken with salt, black pepper, garlic powder, and Italian seasoning.
  2. Heat olive oil in a skillet and cook chicken for 5 to 6 minutes until golden brown. Transfer to the slow cooker.
  3. In the same skillet, melt butter and sauté garlic for 1 minute.
  4. Add heavy cream and milk and simmer for 3 to 4 minutes.
  5. Stir in parmesan cheese until smooth and creamy.
  6. Add spinach and cook until wilted.
  7. Pour the Alfredo sauce over the chicken in the slow cooker.
  8. Cook penne pasta until al dente, then drain.
  9. Add cooked pasta to the slow cooker and toss until evenly coated.
  10. Cover and cook on low for 1 to 2 hours until creamy and heated through.
  11. Garnish with parsley, crushed red pepper flakes, and extra parmesan before serving.

Notes

  • Add mushrooms or broccoli for extra vegetables and texture.
  • Use half-and-half instead of heavy cream for a lighter sauce.
  • Freshly grated parmesan provides the smoothest Alfredo sauce.
  • Store leftovers refrigerated for up to 3 days.
  • Author: lina
  • Prep Time: 20 minutes
  • Cook Time: 1 hour 30 minutes
  • Category: Dinner
  • Method: Slow Cooker
  • Cuisine: Italian-American

Nutrition

  • Serving Size: 1 bowl
  • Calories: 620
  • Sugar: 4 g
  • Sodium: 740 mg
  • Fat: 30 g
  • Saturated Fat: 17 g
  • Unsaturated Fat: 10 g
  • Trans Fat: 0 g
  • Carbohydrates: 42 g
  • Fiber: 3 g
  • Protein: 44 g
  • Cholesterol: 145 mg